TB500: Peptide for Advanced Tissue Recovery and Regeneration—Research Use Only

Contains:

• 1x TB500 5 mg Vial
• 1x Bacteriostatic Water for Injection (with Benzyl Alcohol)

Overzicht

TB500 is a synthetic peptide derived from the naturally occurring protein Thymosine Beta-4, which is essential in cellular repair and regeneration processes. TB500 uniquely enhances the active region of Thymosin Beta-4, facilitating its biological activity while improving stability, shelf life, and usability for research purposes. Each vial contains 5 mg of TB500 in lyophilized powder form, designed for reconstitution in sterile laboratory conditions. This compound is intended strictly for laboratory research and is not for human or veterinary use.

Scientific Background

Thymosine Beta-4 is present in nearly all human and animal cells and is particularly concentrated at sites of tissue injury. It plays a significant role in wound healing, inflammation management, and angiogenesis (formation of new blood vessels), making it a focal point of advanced biomedical research.

TB500 features a synthetically optimized fragment of this larger peptide, isolating the region responsible for actin regulation. This optimization yields a more targeted compound for laboratory investigation, promoting enhanced cellular migration, modulation of inflammatory responses, and tissue regeneration.

Werkingsmechanisme

TB500 primarily functions by promoting the polymerization of actine, a crucial protein for the cytoskeleton in all cells. It aids in cell movement and structural repair by regulating actin activity. The actin-binding properties of TB500 are particularly relevant in models of wound healing and organ regeneration.

Other observed mechanisms erbij betrekken:

• Enhanced migration of stem cells to damaged tissues.
• Stimulation of angiogenesis, leading to improved blood supply in injured areas.
• Downregulation of inflammatory cytokines, contributing to faster recovery.
• Support for nerve and muscle cell regeneration across various tissue types.

TB500 shows promise in research across multiple fields, including ocular damage, cardiovascular repair, and soft tissue injuries.

Research Applications

Although TB500 is not approved for medical use, it has been widely studied in preclinical research settings for its potential in healing and regeneration. Prominent research applications include:

1. Musculoskeletal Repair

2. In animal studies, TB500 has demonstrated its ability to accelerate the recovery of skeletal muscle, tendons, and ligaments post-injury.

3. Cardiovascular Regeneration

4. TB500 is evaluated in cardiac models for angiogenic and anti-fibrotic effects, enhancing healing in environments following myocardial infarctions.

5. Wound Healing and Skin Recovery

6. Early research into dermal wound healing has shown TB500 promotes accelerated epithelialization and collagen deposition in skin injury models.

7. Joint and Tendon Health

8. In arthritis models, TB500 helps reduce swelling and improves flexibility, with studies also suggesting its efficacy in equine models for tendonitis.

9. Nervous System Repair

10. Promising findings indicate that TB500 may assist in axonal regrowth and remyelination, signaling potential for studies involving spinal cord injury or peripheral nerve damage.

Productdetails

• Compound: TB500 (Thymosin Beta-4 fragment)
• Moleculaire formule: C212H350N56O78S
• Moleculair gewicht: ~4963.5 g/mol
• Eenheidgrootte: 5mg
• Verschijning: White lyophilized powder
• Zuiverheid: ≥99% (HPLC verified)
• Verpakking: Sterile, light-resistant ml vial

Opslagcondities:

• Unreconstituted: Store at -20°C.
• Reconstituted: Refrigerate at 2–8°C and use within 20 days.

Oplosbaarheid: Soluble in bacteriostatic or sterile water.

Verified Chemical Identifiers for TB‑500

• CAS-nummer: 885340‑08‑9
• PubChem CID: 62707662
• UNII: QHK6Z47GTG

Handling & Reconstitution

TB500 must be reconstituted using bacteriostatic water for injection to maintain sterility. Gently swirl the vial until fully dissolved—avoid vigorous shaking. Adhere to aseptic techniques and safety protocols at all times when handling these peptides.

Lab Use Only: Not for Human Consumption

This compound is strictly designated for laboratory research purposes only. It is prohibited for human or animal use. By purchasing, you confirm you are qualified to handle this compound in adherence to relevant research guidelines and safety standards.

Comparison: TB500 vs Full-Length Thymosin Beta-4

| Feature | TB500 | Thymosin Beta-4 |
|———————————-|————————–|—————————-|
| Molecular Size | 17 amino acids | 43 amino acids |
| Research Stability | High | Moderate |
| Focused Action | Yes (targeted actin segment) | Broader biological activity |
| Cost Efficiency | More affordable per dose | Higher cost per unit |
| Common in Research Models | Yes | Less common due to instability |

Storage Guidelines

• Keep unreconstituted vials in a dark, frozen environment (-20°C).
• Refrigerate reconstituted solutions (2–8°C).
• Avoid multiple freeze-thaw cycles to maintain stability.
• Best used within 20 days post-mixing.

Purity & Quality Assurance

TB500 is manufactured in GMP-compliant environments and undergoes third-party testing. Each batch comes with a Certificate of Analysis, confirming:

• Amino acid sequence
• Peptide mass (Mass Spectrometry)
• Zuiverheid (HPLC)
• Oplosbaarheid
• pH and sterility

Veelgestelde vragen

• Is this product legal?

• Yes, TB500 can be purchased for research purposes but is not approved for human use.

• How long does it last after reconstitution?

• It is recommended to use it within 20 days when stored correctly.

• Do you provide documentation?

• Each order includes a Certificate of Analysis and supporting lab-grade reference data.

• Can TB500 be shipped internationally?

• Shipping is available to most countries, but you are responsible for compliance with local laws regarding peptides.

Why Choose Us?

• Research-grade quality verified by documentation.
• Tamper-proof packaging to ensure product integrity.
• Responsive support from knowledgeable staff.
• Discreet shipping worldwide.
• Bulk pricing available for institutions.

Order TB500 (5 mg): Research-Grade Peptide

TB500 remains one of the most versatile peptides researched for its potential in tissue repair, wound healing, and anti-inflammatory studies. With dependable quality and comprehensive documentation, we are here to support your lab’s research objectives every step of the way.

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